Prof. Kai Tittmann

Prof. Kai Tittmann

Dept. of Molecular Enzymology
Göttingen Center for Molecular Biosciences
Georg-August-University Göttingen, Germany

Kai Tittmann is the first supervisor of DC6 and member of the Diversity and Inclusion committee.

Kai Tittmann is leading the research group “Molecular Enzymology” at the Göttingen Center of Molecular Biosciences at Göttingen University (Germany) since 2008. He is also a Fellow of the Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany since 2017.
He studied Biochemistry at the Martin-Luther-Universität Halle-Wittenberg, Germany, where he also obtained his PhD in 2000.


Key expertise

Research of the Tittmann lab focuses on the elucidation of the molecular reaction and regulation mechanisms of enzymes as nature’s catalysts by combining protein X-ray crystallography, steady-state and transient kinetic methods, NMR spectroscopy and theoretical studies. Apart from studying fundamental aspects of enzyme catalysis and regulation, his group is also active in protein and drug design as well as biocatalysis.


Hosting Institution

Founded in 1737, Georg-August-Universität Göttingen in Germany is a research university of international renown with strong focus and emphasis on research-led teaching. The University of Göttingen regards its great research tradition and subject diversity as constituting particular strengths. The Georg-August-Universität is also distinguished by being closely integrated into a network of first-class extra-university research establishments involving, amongst others, 5 Max-Planck-Institutes with Life Sciences and Natural Sciences being mainstays of research activities of the Göttingen Campus. Together, these local partners create with the University an alliance for collaboration in research and teaching arguably unique in Germany in terms of its depth and breadth. The group of Prof. Dr. Kai Tittmann is both affiliated with the Göttingen Center of Molecular Biosciences of Göttingen University and with the Max-Planck-Institute for Multidisciplinary Sciences Göttingen. The group of Kai Tittmann is internationally renowned in the areas of enzyme mechanisms, structural enzymology, drug design and biocatalysis with key contributions for various enzyme families. They solved high-resolution X-ray structures of enzymes in complex with critical reaction intermediates, which constituted the basis for biocatalytic applications or drug design. Some projects were/are running in intimate collaboration with industrial partners.




Relevant Publications

1.  Rindfleisch, S. … Tittmann, K. (2022) Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis. Nature Catalysis 5, 332–341.

2. Wensien, M. … Tittmann, K. (2021). A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 593, 460-464.

3.  Dai, S. … Tittmann, K. (2019) Low-barrier hydrogen bonds in enzyme cooperativity. Nature 573, 609–613.